Seipin 远距离调控核脂质滴的形成。

Seipin regulates the formation of nuclear lipid droplets from a distance.

机构信息

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.

出版信息

J Cell Biol. 2021 Jan 4;220(1). doi: 10.1083/jcb.202011166.

DOI:10.1083/jcb.202011166

PMID:33320190

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7745754/

Abstract

Nuclear lipid droplets (nLDs) are poorly characterized outside of the liver. In this issue, Sołtysik et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202005026) show that seipin is absent from the nucleus but seipin deficiency promotes nLD formation by increasing nuclear phosphatidic acid.

摘要

核脂质滴（nLDs）在肝脏以外的组织中特征研究甚少。在本期杂志中，Sołtysik 等人（2020. J. Cell Biol.https://doi.org/10.1083/jcb.202005026）表明 seipin 不存在于核内，但 seipin 缺乏通过增加核内的磷酸脂酸促进 nLD 的形成。