São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, SP, Brazil.
São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, SP, Brazil.
Microbes Infect. 2019 Dec;21(10):432-440. doi: 10.1016/j.micinf.2019.05.003. Epub 2019 Jun 13.
Sporotrichosis is an emergent subcutaneous mycosis of humans and some animals caused by dimorphic fungi of the genus Sporothrix. The disease occurs worldwide but is endemic or hyperendemic in tropical and subtropical areas. The epidemiology of the disease is changing dramatically, and it is now considered an important zoonosis with high morbidity rates, principally in Brazil, and an opportunistic infection in immunocompromised patients. Due to the limited options currently available to treat invasive fungal infections, including sporotrichosis, and the emergence of drug resistance and toxicity, the development of anti-Sporothrix vaccines has become an area of great interest. This work provides a brief analysis of the feasibility of the development of prophylactic and therapeutic vaccines against sporotrichosis, the main advances achieved to date, future challenges and prospects.
孢子丝菌病是一种由申克氏孢子丝菌引起的人类和一些动物的新兴皮下真菌病。这种疾病发生在世界各地，但在热带和亚热带地区流行或高度流行。该疾病的流行病学正在发生巨大变化，现在被认为是一种重要的动物源性传染病，发病率高，主要在巴西，并且是免疫功能低下患者的机会性感染。由于目前治疗包括孢子丝菌病在内的侵袭性真菌感染的选择有限，以及耐药性和毒性的出现，因此开发抗孢子丝菌疫苗已成为一个非常关注的领域。这项工作简要分析了开发预防和治疗孢子丝菌病疫苗的可行性，以及迄今为止取得的主要进展、未来的挑战和前景。
