一种含吡唑的腙，可用于溶酶体中铝的荧光成像，以及由此得到的作为 F 传感器的铝配合物。
A pyrazole-containing hydrazone for fluorescent imaging of Al in lysosomes and its resultant Al complex as a sensor for F.
机构信息
College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China.
College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China.
出版信息
Talanta. 2019 Oct 1;203:178-185. doi: 10.1016/j.talanta.2019.05.051. Epub 2019 May 14.
A fluorescence-enhanced and lysosome-targeted Al probe (1) based on a pyrazole-containing hydrazone was developed in this work. The fluorescent probe 1 displays an OFF-ON fluorescence response to Al in the lysosome pH environment. In addition, the resultant 1-Al complex could act as an ON-OFF fluorescence sensor for F. Fluorescence imaging shows that 1 is suitable for visualization of Al in lysosomes of HeLa cells.
本工作开发了一种基于含吡唑腙的荧光增强和溶酶体靶向 Al 探针（1）。荧光探针 1 在溶酶体 pH 环境中对 Al 表现出 OFF-ON 荧光响应。此外，所得的 1-Al 配合物可以作为 F 的 ON-OFF 荧光传感器。荧光成像表明 1 适用于 HeLa 细胞溶酶体中 Al 的可视化。
Zotero 插件