Supramolecular and Organometallic Chemistry Lab, Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
Supramolecular and Organometallic Chemistry Lab, Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 5;230:117993. doi: 10.1016/j.saa.2019.117993. Epub 2019 Dec 29.
New pyrazole bearing imidazole derivative was successfully synthesized and thoroughly characterized by various spectroanalytical techniques. The sensor DIBI shows a highly selective and sensitive fluorescent response with the addition of Al/Fe ions in acetonitrile-water mixture. The strong fluorescent molecule exhibits a notable ratiometric emissions at 462 nm and 470 nm for Al and Fe ions, respectively (λ = 280 nm). Job's plot studies conclude that the coordination between DIBI with Al/Fe was 1:1 binding stoichiometry. The limit of detection of DIBI with Al/Fe was calculated as 2.12 × 10 M and 1.73 × 10 M, respectively. The TD-DFT calculations further supported the photonics performances of the free probe and its complexes. The reversibility and reusability of the sensor molecule are studied using EDTA. The probe was used to track Al/Fe in cancer cells via fluorescence microscopy.
新型吡唑并咪唑衍生物成功合成，并通过各种光谱分析技术进行了彻底的表征。传感器 DIBI 在乙腈-水混合溶液中加入 Al/Fe 离子时，表现出高度选择性和灵敏的荧光响应。强荧光分子在 462nm 和 470nm 处分别对 Al 和 Fe 离子表现出明显的比率荧光发射（λ=280nm）。Job 图研究表明，DIBI 与 Al/Fe 的配位比为 1:1。DIBI 与 Al/Fe 的检测限分别计算为 2.12×10-6M 和 1.73×10-6M。TD-DFT 计算进一步支持了自由探针及其配合物的光子性能。使用 EDTA 研究了传感器分子的可逆性和可重复使用性。通过荧光显微镜，探针被用于跟踪癌细胞中的 Al/Fe。
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