Tigreros Alexis, Portilla Jaime
Department of Chemistry, Bioorganic Compounds Research Group, Universidad de los Andes Carrera 1 No. 18A-10 Bogotá 111711 Colombia
RSC Adv. 2020 May 22;10(33):19693-19712. doi: 10.1039/d0ra02394a. eCollection 2020 May 20.
Colorimetric and fluorescent probes based on small organic molecules have become important tools in modern biology because they provide dynamic information concerning the localization and quantity of the molecules and ions of interest without the need for genetic engineering of the sample. In the past five years, these probes for ions and molecules have attracted great attention because of their biological, environmental and industrial significance combined with the simplicity and high sensitivity of absorption and fluorescence techniques. Moreover, pyrazole derivatives display a number of remarkable photophysical properties and wide synthetic versatility superior to those of other broadly used scaffolds. This review provides an overview of the recent (2016-2020) findings on chemosensors containing pyrazole derivatives (pyrazoles, pyrazolines and fused pyrazoles). The discussion focuses on the design and physicochemical properties of chemosensors in order to realize their full potential for practical applications in environmental and biological monitoring (sensing of metal ions, anions, explosives, and biomolecules). We also present our conclusions and outlook for the future.
基于小分子有机化合物的比色和荧光探针已成为现代生物学中的重要工具，因为它们能够提供有关目标分子和离子的定位及数量的动态信息，而无需对样本进行基因工程操作。在过去五年中，这些用于离子和分子的探针因其在生物学、环境和工业方面的重要意义，以及吸收和荧光技术的简便性和高灵敏度而备受关注。此外，吡唑衍生物具有许多卓越的光物理性质，且合成通用性广泛，优于其他广泛使用的支架结构。本综述概述了近期（2016 - 2020年）关于含吡唑衍生物（吡唑、吡唑啉和稠合吡唑）的化学传感器的研究成果。讨论聚焦于化学传感器的设计和物理化学性质，以充分发挥其在环境和生物监测（金属离子、阴离子、爆炸物和生物分子传感）实际应用中的潜力。我们还给出了结论和对未来的展望。
