Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
J Mol Biol. 2019 Oct 4;431(21):4281-4289. doi: 10.1016/j.jmb.2019.06.002. Epub 2019 Jun 14.
The pattern recognition receptors RIG-I-like receptors (RLRs) are critical molecules for cytosolic viral recognition and for subsequent activation of type I interferon production. The interferon signaling pathway plays a key role in viral detection and generating antiviral responses. Among the many pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of mechanisms. Here, I review the current state of knowledge on the molecular mechanisms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs.
模式识别受体 RIG-I 样受体(RLRs)是细胞质病毒识别和随后激活 I 型干扰素产生的关键分子。干扰素信号通路在病毒检测和产生抗病毒反应中起着关键作用。在众多病原体中,非节段负义 RNA 病毒利用多种机制靶向 RLR 途径。在这里,我回顾了允许非节段负义 RNA 病毒识别和拮抗 RLR 的分子机制的最新知识。