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甲型流感病毒非结构蛋白 1（NS1）的研究进展。

Research progress on the nonstructural protein 1 (NS1) of influenza a virus.

机构信息

College of Animal Science and Technology, Ningxia University, Yinchuan, China.

School of Biological Science and Technology, University of Jinan, Jinan, China.

出版信息

Virulence. 2024 Dec;15(1):2359470. doi: 10.1080/21505594.2024.2359470. Epub 2024 Jun 25.

DOI:10.1080/21505594.2024.2359470
PMID:38918890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11210920/
Abstract

Influenza A virus (IAV) is the leading cause of highly contagious respiratory infections, which poses a serious threat to public health. The non-structural protein 1 (NS1) is encoded by segment 8 of IAV genome and is expressed in high levels in host cells upon IAV infection. It is the determinant of virulence and has multiple functions by targeting type Ι interferon (IFN-I) and type III interferon (IFN-III) production, disrupting cell apoptosis and autophagy in IAV-infected cells, and regulating the host fitness of influenza viruses. This review will summarize the current research on the NS1 including the structure and related biological functions of the NS1 as well as the interaction between the NS1 and host cells. It is hoped that this will provide some scientific basis for the prevention and control of the influenza virus.

摘要

甲型流感病毒（IAV）是高度传染性呼吸道感染的主要原因，对公众健康构成严重威胁。非结构蛋白 1（NS1）由 IAV 基因组的第 8 节编码，在 IAV 感染后在宿主细胞中高水平表达。它是毒力的决定因素，具有多种功能，包括靶向 I 型干扰素（IFN-I）和 III 型干扰素（IFN-III）的产生、破坏 IAV 感染细胞中的细胞凋亡和自噬、以及调节流感病毒的宿主适应性。这篇综述将总结 NS1 的当前研究，包括 NS1 的结构和相关生物学功能，以及 NS1 与宿主细胞的相互作用。希望这将为流感病毒的预防和控制提供一些科学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/16e158bb9bda/KVIR_A_2359470_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/4c47acc29736/KVIR_A_2359470_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/370d7045f8bf/KVIR_A_2359470_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/f191af791f07/KVIR_A_2359470_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/16e158bb9bda/KVIR_A_2359470_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/4c47acc29736/KVIR_A_2359470_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/370d7045f8bf/KVIR_A_2359470_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/f191af791f07/KVIR_A_2359470_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85fb/11210920/16e158bb9bda/KVIR_A_2359470_F0004_OC.jpg

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