海洋来源真菌 SCSIO 00305 中新型吡喃酮和环戊烯酮衍生物。
New pyrone and cyclopentenone derivatives from marine-derived fungus SCSIO 00305.
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Institution of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangdong, Guangzhou, China.
University of the Chinese Academy of Sciences, Beijing, China.
出版信息
Nat Prod Res. 2021 Jan;35(2):318-326. doi: 10.1080/14786419.2019.1629919. Epub 2019 Jun 17.
Two new 2-pyrone derivatives sydowiones A-B (, ), one new cyclopentenone derivative sydowione C (), and one new mycotoxin 6-methoxyl austocystin A () along with two known analogues paecilpyrone A () and austocystin A (), were isolated from the marine-derived fungus SCSIO 00305. The structures of - were elucidated by extensive spectroscopic analysis. The absolute configuration of C-8 in was established by Mosher method, and further confirmed by calculation of the electronic circular dichroism (ECD) spectra. The absolute configuration of C-11 in was also determined by calculation of ECD spectra. The absolute configuration of was determined by a single-crystal X-ray diffraction experiment for the first time. Compounds showed moderate toxicity towards brine shrine naupalii with LC values of 19.5, 14.3, 8.3 and 2.9 μM, respectively. And and also showed antioxidant activity against 2,2-diphenyl-picrylhydrazyl (DPPH) radicals with IC values of 46.0 and 46.6 μM, respectively.[Formula: see text].
从海洋来源真菌 SCSIO 00305 中分离得到了两个新的 2-吡喃酮衍生物 sydowiones A-B（1，2），一个新的环戊烯酮衍生物 sydowione C（3），一个新的真菌毒素 6-甲氧基 austocystin A（4），以及两个已知类似物 paecilpyrone A（5）和 austocystin A（6）。通过广泛的光谱分析阐明了 1-4 的结构。通过 Mosher 方法确定了 C-8 在 C 中的绝对构型，并通过计算电子圆二色（ECD）光谱进一步证实。通过计算 ECD 光谱确定了 4 中 C-11 的绝对构型。通过单晶 X 射线衍射实验首次确定了 5 的绝对构型。化合物 1-3 对卤虫的 LC 值分别为 19.5、14.3、8.3 和 2.9 μM，表现出中等毒性。5 和 6 还表现出对 2,2-二苯基-1-苦基肼（DPPH）自由基的抗氧化活性，IC 值分别为 46.0 和 46.6 μM。[公式：见文本]。
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