Preparatory Year Program, Department of Chemistry, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Mar Drugs. 2023 Aug 5;21(8):441. doi: 10.3390/md21080441.
Marine-derived fungi are renowned as a source of astonishingly significant and synthetically appealing metabolites that are proven as new lead chemicals for chemical, pharmaceutical, and agricultural fields. is a saprotrophic, ubiquitous, and halophilic fungus that is commonly found in different marine ecosystems. This fungus can cause aspergillosis in sea fan corals leading to sea fan mortality with subsequent changes in coral community structure. Interestingly, is a prolific source of distinct and structurally varied metabolites such as alkaloids, xanthones, terpenes, anthraquinones, sterols, diphenyl ethers, pyrones, cyclopentenones, and polyketides with a range of bioactivities. has capacity to produce various enzymes with marked industrial and biotechnological potential, including α-amylases, lipases, xylanases, cellulases, keratinases, and tannases. Also, this fungus has the capacity for bioremediation as well as the biocatalysis of various chemical reactions. The current work aimed at focusing on the bright side of this fungus. In this review, published studies on isolated metabolites from , including their structures, biological functions, and biosynthesis, as well as the biotechnological and industrial significance of this fungus, were highlighted. More than 245 compounds were described in the current review with 134 references published within the period from 1975 to June 2023.
海洋来源真菌是一类具有重要意义的代谢产物的重要来源,这些代谢产物已被证明是化学、制药和农业领域的新型先导化合物。是一种腐生的、普遍存在的、嗜盐的真菌,通常存在于不同的海洋生态系统中。这种真菌可以引起扇珊瑚的曲霉病,导致扇珊瑚死亡,随后珊瑚群落结构发生变化。有趣的是,是一种丰富的独特和结构多样的代谢产物的来源,如生物碱、黄酮类、萜类、蒽醌类、甾醇类、二苯醚类、吡喃酮类、环戊烯酮类和聚酮类,具有广泛的生物活性。具有产生各种具有显著工业和生物技术潜力的酶的能力,包括α-淀粉酶、脂肪酶、木聚糖酶、纤维素酶、角蛋白酶和单宁酶。此外,这种真菌还具有生物修复和各种化学反应的生物催化能力。本研究旨在关注该真菌的积极方面。在这篇综述中,重点介绍了从该真菌中分离得到的代谢产物的研究进展,包括它们的结构、生物功能和生物合成,以及该真菌的生物技术和工业意义。目前的综述描述了超过 245 种化合物,其中 134 种参考文献的发表时间为 1975 年至 2023 年 6 月。