深海来源真菌 sp. SCSIO z015 的新桔青霉素衍生物。

New citrinin derivatives from the deep-sea-derived fungus sp. SCSIO z015.

机构信息

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong, China.

University of the Chinese Academy of Sciences, Beijing, China.

出版信息

Nat Prod Res. 2020 May;34(9):1219-1226. doi: 10.1080/14786419.2018.1556266. Epub 2019 Jan 19.

DOI:10.1080/14786419.2018.1556266

PMID:30663375

Abstract

During the course of our search for novel bioactive compounds from marine fungi, four new citrinin derivatives, cladosporins A-D () were isolated from a culture broth of the deep-sea-derived fungus sp. SCSIO z015. Their complete structural assignments were elucidated by the extensive spectroscopic investigation. The absolute configurations of - were established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compounds showed weak toxicity towards brine shrine naupalii with LC values of 72.0, 81.7, 49.9 and 81.4 μM, respectively. And also showed significant antioxidant activity against ɑ,α-diphenyl-picrylhydrazyl (DPPH) radicals with an IC value of 16.4 μM.

摘要

在从海洋真菌中寻找新型生物活性化合物的过程中，我们从深海来源的真菌 sp. SCSIO z015 的发酵液中分离得到了四个新的桔青霉素衍生物，分别命名为 cladosporins A-D ()。通过广泛的光谱研究阐明了它们完整的结构。通过电子圆二色性（ECD）光谱的量子化学计算确定了 - 的绝对构型。化合物对盐水卤虫表现出较弱的毒性，LC 值分别为 72.0、81.7、49.9 和 81.4 μM。并且对 α,α-二苯基-1-苦基肼（DPPH）自由基也表现出显著的抗氧化活性，IC 值为 16.4 μM。