海洋柳珊瑚来源真菌 SCSIO 41501 中的新生物碱和异香豆素。
New alkaloids and isocoumarins from the marine gorgonian-derived fungus SCSIO 41501.
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China.
University of the Chinese Academy of Sciences, Beijing, China.
出版信息
Nat Prod Res. 2020 Jul;34(14):1992-2000. doi: 10.1080/14786419.2019.1569660. Epub 2019 Feb 14.
Two new -carboline alkaloids, aspergillspins A-B (-), three new quinolone alkaloids, aspergillspins C-E (-), and two new isocoumarins, aspergillspins F-G (-), together with four known alkaloids were isolated from the marine gorgonian-derived fungus sp. SCSIO 41501. Their structures were identified by spectroscopic analysis, and the absolute configurations of several chiral carbons in and were further established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Their cytotoxic and antibacterial activities were also evaluated.
从海洋柳珊瑚来源真菌 Aspergillus sp. SCSIO 41501 中分离得到两个新的 - 咔啉生物碱aspergillspins A-B (-)，三个新的喹诺酮生物碱aspergillspins C-E (-)和两个新的异香豆素aspergillspins F-G (-)，以及四个已知的生物碱。通过光谱分析鉴定了它们的结构，并且通过电子圆二色性（ECD）光谱的量子化学计算进一步确定了和中的几个手性碳原子的绝对构型。还评估了它们的细胞毒性和抗菌活性。
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