From the Poison Control Centre.
Representative of Clinical Research and Innovation, and.
J Clin Psychopharmacol. 2019 Jul/Aug;39(4):312-317. doi: 10.1097/JCP.0000000000001053.
PURPOSE/BACKGROUND: Quetiapine is a relatively new atypical antipsychotic with fewer adverse effects. It is increasingly prescribed to patients. The purpose of this study was to describe the cases of poisoning observed at the western France Poison Control Centre and identify potential risk factors that increase the severity of the cases.
This was a retrospective study of self-poisoning with quetiapine as reported by the western France Poison Control Centre between 2007 and 2017.
There were 372 cases of quetiapine poisoning. Circumstances are known in 367 of 372 cases. There were 75 cases of null severity (grade 0), 133 cases of mild severity (grade 1), 85 cases of moderate severity (grade 2), and 79 cases of high severity (grade 3). Five deaths were listed in this series. The most commonly observed symptoms were neurological and cardiovascular in nature (drowsiness, coma, tachycardia, hypotension). Of these cases, 79.8% included voluntary ingestions. Among 302 cases with coagents, the most common coagents were benzodiazepines (56%), other psychotropic drugs (41%), and antidepressants (37%). An evaluated ingested dose 1500 mg or greater and 2 or more coagents increase the risk of severe poisoning. In particular, concomitant ingestion of benzodiazepines and antidepressants with quetiapine was associated with high severity (odds ratio, 2.478 [confidence interval, 1.3-4.723]; odds ratio, 1.820 [confidence interval, 1.010-3.316]).
Quetiapine may lead to severe poisoning for which there is currently no specific treatment. Patients and practitioners should be aware of this when quetiapine is prescribed, particularly when used in combination with other medications, and in order to deal with cases of poisoning.
目的/背景：喹硫平是一种新型的抗精神病药，副作用较少。它越来越多地被开给患者。本研究的目的是描述法国西部中毒控制中心观察到的中毒病例，并确定可能增加病例严重程度的潜在危险因素。
这是一项回顾性研究，对 2007 年至 2017 年法国西部中毒控制中心报告的喹硫平自我中毒病例进行了研究。
共发生 372 例喹硫平中毒。372 例中有 367 例的情况已知。其中 75 例为无严重程度（0 级），133 例为轻度严重程度（1 级），85 例为中度严重程度（2 级），79 例为重度严重程度（3 级）。该系列中列出了 5 例死亡。最常见的观察到的症状是神经和心血管性质的（嗜睡、昏迷、心动过速、低血压）。在这些病例中，79.8%是自愿摄入的。在 302 例有共服药物的病例中，最常见的共服药物是苯二氮䓬类（56%）、其他精神药物（41%）和抗抑郁药（37%）。评估的摄入剂量为 1500 毫克或更大，以及 2 种或更多共服药物会增加严重中毒的风险。特别是，同时服用苯二氮䓬类和抗抑郁药与喹硫平合用与严重程度相关（比值比，2.478[置信区间，1.3-4.723]；比值比，1.820[置信区间，1.010-3.316]）。
喹硫平可能导致目前尚无特效治疗的严重中毒。当开喹硫平时，患者和医生都应该意识到这一点，特别是当与其他药物联合使用时，并且为了处理中毒病例。
