Brown E W, Riccardi V M, Mawad M, Handel S, Goldman A, Bryan R N
Department of Radiology, Baylor College of Medicine, Houston, TX 77030.
AJNR Am J Neuroradiol. 1987 Nov-Dec;8(6):1031-6.
Twenty-one patients with documented neurofibromatosis had MR examinations to evaluate possible intracranial disease. In five cases the indication was a known or suspected optic glioma. Two patients were examined because of a history of seizures; the rest were examined as part of a baseline evaluation. Eighteen patients showed evidence of signal hyperintensity on T2-weighted images. Lesions involved the optic nerves, optic chiasm, optic tracts, lateral geniculate body, optic radiations, basal ganglia, periventricular white matter, cerebellar white matter, and dentate nucleus of the cerebellum. Comparison between MR and concurrent CT scans showed MR to be superior in demonstrating the posterior extent of optic-pathway gliomas. In addition, MR showed focal areas of hyperintensity in the basal ganglia, internal capsule, cerebellum, and/or white matter that were not detected on CT. Although we found MR to be superior to CT in detecting intracranial tumors in patients with neurofibromatosis, and in evaluating the extensive involvement of known lesions, the full clinical implications of our findings remain to be determined.
21例确诊为神经纤维瘤病的患者接受了磁共振成像（MR）检查，以评估可能存在的颅内病变。其中5例的检查指征为已知或疑似视神经胶质瘤。2例患者因有癫痫病史而接受检查；其余患者作为基线评估的一部分接受检查。18例患者在T2加权图像上显示出信号高强化的证据。病变累及视神经、视交叉、视束、外侧膝状体、视辐射、基底神经节、脑室周围白质、小脑白质和小脑齿状核。MR与同期CT扫描的比较显示，在显示视神经通路胶质瘤的后部范围方面，MR更具优势。此外，MR还显示出基底神经节、内囊、小脑和/或白质中的局灶性高强化区域，而这些区域在CT上未被检测到。尽管我们发现MR在检测神经纤维瘤病患者的颅内肿瘤以及评估已知病变的广泛累及方面优于CT，但我们这些发现的全部临床意义仍有待确定。
