Dai Xianjin, Qian Weiping, Yang Hao, Yang Lily, Jiang Huabei
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Departments of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Appl Sci (Basel). 2017 Dec;7(12). doi: 10.3390/app7121241. Epub 2017 Nov 30.
It is highly desirable to develop novel approaches to improve patient survival rate of pancreatic cancer through early detection. Here, we present such an approach based on photoacoustic and fluorescence molecular imaging of pancreatic tumor using a miniature multimodal endoscope in combination with targeted multifunctional iron oxide nanoparticles (IONPs). A novel fan-shaped scanning mechanism was developed to minimize the invasiveness for endoscopic imaging of pancreatic tumors. The results show that the enhancements in photoacoustic and fluorescence signals using amino-terminal fragment (ATF) targeted IONPs were ~four to six times higher compared to that using non-targeted IONPs. Our study indicates the potential of the combination of the multimodal photoacoustic-fluorescence endoscopy and targeted multifunctional nanoparticles as an efficient tool to provide improved specificity and sensitivity for pancreatic cancer detection.
通过早期检测开发新方法以提高胰腺癌患者生存率是非常必要的。在此，我们展示了一种基于使用微型多模态内窥镜结合靶向多功能氧化铁纳米颗粒（IONPs）对胰腺肿瘤进行光声和荧光分子成像的方法。开发了一种新型扇形扫描机制，以尽量减少胰腺肿瘤内窥镜成像的侵入性。结果表明，与使用非靶向IONPs相比，使用氨基末端片段（ATF）靶向IONPs时光声和荧光信号的增强约高四到六倍。我们的研究表明，多模态光声-荧光内窥镜检查与靶向多功能纳米颗粒相结合，有潜力成为一种高效工具，为胰腺癌检测提供更高的特异性和灵敏度。
