宫颈癌中的神经周围浸润：关注保留神经的根治性子宫切除术的指征。
Perineural invasion in cervical cancer: pay attention to the indications of nerve-sparing radical hysterectomy.
作者信息
Zhu Yi, Zhang Guo-Nan, Shi Yu, Cui Ling, Leng Xue-Feng, Huang Jian-Ming
机构信息
Department of Gynecologic Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
Department of Ultrasound, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
出版信息
Ann Transl Med. 2019 May;7(9):203. doi: 10.21037/atm.2019.04.35.
Perineural invasion (PNI) in early-stage cervical cancer, is associated with multiple high-risk factors and represents a poor outcome in the patients. For nerve-sparing radical hysterectomy (NSRH) to become a standard and widely used treatment for cervical cancer, we need to define its oncological safety, and to establish standardized surgical procedures and indications of NSRH. Here, we review the definition and mechanisms, and clinical significance of PNI in cervical cancer, and discuss the indications of NSRH. PNI should be regarded as one of the main pathological features of cervical cancer and a factor affecting prognosis. A deeper understanding of PNI in cervical cancer, hopefully, will provide clear indications of NSRH.
早期宫颈癌的神经周围浸润（PNI）与多种高危因素相关，提示患者预后不良。为使保留神经的根治性子宫切除术（NSRH）成为宫颈癌的标准且广泛应用的治疗方法，我们需要明确其肿瘤学安全性，并建立NSRH的标准化手术程序和适应证。在此，我们综述了宫颈癌中PNI的定义、机制及临床意义，并讨论了NSRH的适应证。PNI应被视为宫颈癌的主要病理特征之一及影响预后的因素。对宫颈癌中PNI的深入理解有望为NSRH提供明确的适应证。
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