Department of Medical Statistics and Epidemiology, School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, PR China.
Department of Gynecology, Guangdong Women and Children Hospital, Guangzhou, Guangdong, PR China.
J Med Virol. 2019 Oct;91(10):1856-1865. doi: 10.1002/jmv.25520. Epub 2019 Jul 3.
Our study aimed to analyze genotype-specific, age-specific prevalence, and year-on-year trend of cervical human papillomavirus (HPV) detection among women in Guangdong, China 2008 to 2017. A total of 199 963 women attending the gynecological department and 11 999 women attending the medical examination center at Guangdong Women and Children Hospital were included. Prevalent HPV detection significantly differed between these two groups of women (20.16% vs 17.25%; P < .001). HPV genotypes of these two populations have a large overlap, with HPV52, 16, 58, CP8304, and 53 being the dominant subtypes among gynecological outpatients and HPV52, CP8304, 58, 53, and 16 among women receiving physical examinations. The distribution of prevalent HPV detection showed a bimodal pattern across age groups among these two populations. However, prevalent HPV detection among these two populations exhibited different trends from 2008 to 2017. Our study demonstrated that prevalent HPV detection among women in Guangdong is associated with age and different from that among women from other regions of China. Our study may provide valuable data to inform cervical cancer screening and HPV vaccination programs for women in this province.
本研究旨在分析 2008 年至 2017 年期间中国广东省女性中 HPV 基因型特异性、年龄特异性流行率及逐年变化趋势。共纳入广东妇女儿童医院妇科门诊 199963 例和体检中心 11999 例女性。两组女性 HPV 流行率差异有统计学意义（20.16% vs 17.25%；P<0.001）。两组人群 HPV 基因型有较大重叠，妇科门诊患者以 HPV52、16、58、CP8304 和 53 为优势亚型，体检女性以 HPV52、CP8304、58、53、16 为优势亚型。两组人群 HPV 流行率随年龄呈双峰分布，但 2008 年至 2017 年间流行率变化趋势不同。本研究表明广东女性 HPV 流行率与年龄相关，与中国其他地区女性不同。本研究可为该省女性宫颈癌筛查和 HPV 疫苗接种项目提供有价值的数据。
