人乳头瘤病毒的流行率及基因型分布：对中国河南省癌症筛查和疫苗接种的启示
Prevalence and genotype distribution of human papillomavirus: implications for cancer screening and vaccination in Henan province, China.
作者信息
Zhao Jun-Wei, Xu Jing-Jing, Yan Min, Sun Xiao-Xu, Shi Guang, Ming Liang
机构信息
Clinical Laboratory, Key Clinical Laboratory of Henan Province, Zhengzhou University, Zhengzhou, China.
Department of pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
出版信息
Rev Soc Bras Med Trop. 2016 Apr;49(2):237-40. doi: 10.1590/0037-8682-0192-2015.
INTRODUCTION
To provide information for cervical cancer screening and vaccination in Henan province, China, the distribution of human papillomavirus (HPV) was analyzed.
METHODS
The HPV genotypes were detected using gene array and flow-through hybridization.
RESULTS
Overall, 38.1% (1,536/4,033) of the women were human papillomavirus deoxyribonucleic acid (HPV DNA) positive. The prevalence of high-risk HPV types was 32.4%. HPV 16 was the most prevalent genotype (8.9%), followed by HPV 52 (5.8%) and HPV 58 (4.4%).
CONCLUSIONS
The data support close surveillance of women for cervical cancer screening, and HPV prophylactic vaccines including HPV16, HPV 52, and HPV 58 might offer greater protection in this area.
引言
为了提供中国河南省宫颈癌筛查和疫苗接种的信息，对人乳头瘤病毒（HPV）的分布进行了分析。
方法
采用基因芯片和流式杂交技术检测HPV基因型。
结果
总体而言，38.1%（1536/4033）的女性人乳头瘤病毒脱氧核糖核酸（HPV DNA）呈阳性。高危HPV类型的患病率为32.4%。HPV 16是最常见的基因型（8.9%），其次是HPV 52（5.8%）和HPV 58（4.4%）。
结论
这些数据支持对女性进行密切的宫颈癌筛查监测，包括HPV16、HPV 52和HPV 58在内的HPV预防性疫苗可能在该地区提供更大的保护。
Zotero 插件