人成纤维细胞聚（ADP - 核糖）聚合酶全长cDNA的核苷酸序列。
Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.
作者信息
Uchida K, Morita T, Sato T, Ogura T, Yamashita R, Noguchi S, Suzuki H, Nyunoya H, Miwa M, Sugimura T
机构信息
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
出版信息
Biochem Biophys Res Commun. 1987 Oct 29;148(2):617-22. doi: 10.1016/0006-291x(87)90921-1.
The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3' untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.
测定了人成纤维细胞聚（ADP - 核糖）聚合酶cDNA的完整核苷酸序列。该cDNA包含一个编码1014个氨基酸多肽的开放阅读框。在聚（ADP - 核糖）聚合酶的DNA结合结构域中，预测存在α - 螺旋 - 转角 - α - 螺旋结构以及两个彼此相似的约100个氨基酸的序列，其中含有潜在的半胱氨酸 - 锌DNA结合结构。在3'非翻译区内，有一个富含AT的序列，包含ATTTA，这可能是一种mRNA去稳定剂。
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