Mizerski J, Noworolski J, Zembala M
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):411-5.
The effect of the lymphocytes from picryl sulfonic acid treatment animals on primary and secondary humoral immune response to TNP hapten was investigated. These cells known to inhibit contract sensitivity reactions were also able to depress primary IgM response. When peritoneal exudate cells from normal mice incubated in suppressor supernatant were transferred into primed mice the suppression of IgM but no IgM secondary response was observed. In contrast peritoneal exudate cells incubated in control supernatant augmented IgM but didn't affect IgG response. It is postulated that normal peritoneal exudate cells (presumably macrophages) can stimulate IgM response. This enhancing activity could be partially blocked by soluble suppressor factor.
研究了来自苦味酸磺酸处理动物的淋巴细胞对TNP半抗原的初次和二次体液免疫反应的影响。这些已知能抑制接触敏感性反应的细胞也能够抑制初次IgM反应。当将在抑制性上清液中孵育的正常小鼠腹腔渗出细胞转移到致敏小鼠中时，观察到对IgM的抑制，但未观察到IgM二次反应。相反，在对照上清液中孵育的腹腔渗出细胞增强了IgM，但不影响IgG反应。据推测，正常的腹腔渗出细胞（可能是巨噬细胞）可以刺激IgM反应。这种增强活性可能会被可溶性抑制因子部分阻断。
