Department of Healthcare Administration, Asia University, Taichung 41354, Taiwan.
Tissue Bank, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Int J Mol Sci. 2019 Jun 16;20(12):2940. doi: 10.3390/ijms20122940.
Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5-15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.
口腔黏膜下纤维性变（OSF）的特征是异常的胶原沉积。它是一种癌前疾病，在所有病例中，有 1.5%-15%会转化为恶性肿瘤。症状包括黏膜下纤维化、溃疡、口干、烧灼感和张口受限。所有这些都极大地干扰了患者的生活质量。本综述从分子角度介绍 OSF，并总结其潜在机制、诊断生物标志物和治疗干预的已知内容。除了积极治疗 OSF 外，预防也很重要。因此，未来的研究应侧重于提高易患 OSF 患者的口腔健康素养。
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