Rathod Yogesh G, Kulkarni Sunita P, Khairnar Mahesh R, Joshi Purushottam N, Patle Bhaskar K, Pagare Jaishree S
Department of Oral Medicine & Radiology, Government Dental College and Hospital, Aurangabad, Maharashtra, India.
Department of Oral Medicine & Radiology, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, Maharashtra, India.
J Exp Ther Oncol. 2018 Nov;12(4):267-271.
Oral submucous fibrosis (OSMF), an insidious disease, has not been widely studied with respect to levels of serum beta-carotene (b-carotene). Hence present study aimed to estimate level of serum beta carotene in patients with OSMF.
40 subjects (study subjects) with different grades of OSMF and 40 apparently healthy subjects without OSMF (control subjects with age and sex matched as that of study subjects) were screened for serum b-carotene levels employing Sobel and Snow's method. Subjects in both the groups had areca nut or gutkha chewing habit.
Study subjects with OSMF showed lower levels of serum b-carotene as compared to control group subjects without OSMF. When the levels were compared between different disease stages, least levels of serum b-carotene were seen in Grade III OSMF subjects, as compared with Grade I and II subjects. Females showed higher levels of serum b-carotene than males in both the groups. Smokers showed depleted levels as compared to non-smokers in both groups.
b-carotene plays an important role in the pathogenesis of OSMF, and its level decreases with disease progression.
口腔黏膜下纤维化（OSMF）是一种隐匿性疾病，关于血清β-胡萝卜素水平的研究尚未广泛开展。因此，本研究旨在评估口腔黏膜下纤维化患者的血清β-胡萝卜素水平。
采用索贝尔和斯诺的方法，对40名不同等级的口腔黏膜下纤维化患者（研究对象）和40名明显健康且无口腔黏膜下纤维化的受试者（年龄和性别与研究对象匹配的对照受试者）进行血清β-胡萝卜素水平筛查。两组受试者均有槟榔或古特卡咀嚼习惯。
与无口腔黏膜下纤维化的对照组受试者相比，患有口腔黏膜下纤维化的研究对象血清β-胡萝卜素水平较低。在比较不同疾病阶段的水平时，与I级和II级受试者相比，III级口腔黏膜下纤维化受试者的血清β-胡萝卜素水平最低。两组中女性的血清β-胡萝卜素水平均高于男性。两组中吸烟者的血清β-胡萝卜素水平均低于非吸烟者。
β-胡萝卜素在口腔黏膜下纤维化的发病机制中起重要作用，其水平随疾病进展而降低。
