Pan Chen-Wei, Qian Yu-Xi, Zhong Hua, Li Jun, Liu Hu, Chen Qin
School of Public Health, Medical College of Soochow University , Suzhou , China.
Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University , Kunming , China.
Ophthalmic Epidemiol. 2019 Oct;26(5):360-366. doi: 10.1080/09286586.2019.1632903. Epub 2019 Jun 18.
: To examine the distribution and determinants of central corneal thickness (CCT) including birth weight and gestational age in a school-based samples of Grade 7 students in rural China. : 2346 (93.5%) grade 7 students with a mean age of 13.8 years participated in the study. CCT was measured for both eyes using the LenStar LS900. Information regarding birth weight and gestational age was retrieved from the participants' delivery records. A linear regression model was established to examine the relationship of birth weight, gestational age and other factors with CCT. : The mean CCT in this population was 534.7 µm and boys had a greater CCT compared with girls ( = .06). CCT was positively related to axial length (r = 0.056) while negatively related to anterior chamber depth (r = -0.076) and corneal power (r = -0.105) . In multivariate analyses, the cornea was 19.35µm thinner in individuals with low birth weight compared with those with normal. In addition, the cornea was 25.25µm thinner in prematurely born adolescents compared with full-term ones. The combined effect of birth weight and gestational age on CCT was not statistically significant ( for interaction = 0.12) : Low birth weight and small gestational age are associated with thinner corneas in adolescence. This disparity across groups with different levels of birth parameters should be taken into account by future studies investigating CCT as risk factors or diagnostic tests for glaucoma.
在中国农村七年级学生的校本样本中，研究中央角膜厚度（CCT）的分布及其决定因素，包括出生体重和孕周。2346名（93.5%）平均年龄为13.8岁的七年级学生参与了该研究。使用LenStar LS900测量双眼的CCT。从参与者的分娩记录中获取有关出生体重和孕周的信息。建立线性回归模型以研究出生体重、孕周和其他因素与CCT的关系。该人群的平均CCT为534.7μm，男孩的CCT比女孩更大（P = 0.06）。CCT与眼轴长度呈正相关（r = 0.056），而与前房深度呈负相关（r = -0.076），与角膜曲率呈负相关（r = -0.105）。在多变量分析中，低出生体重者的角膜比正常出生体重者薄19.35μm。此外，早产青少年的角膜比足月出生者薄25.25μm。出生体重和孕周对CCT的联合效应无统计学意义（交互作用P = 0.12）。低出生体重和小孕周与青少年期较薄的角膜有关。未来研究将CCT作为青光眼的危险因素或诊断测试时，应考虑不同出生参数水平组之间的这种差异。
