Suraj Eye Institute, Nagpur, India.
Ophthalmology. 2010 Apr;117(4):705-10. doi: 10.1016/j.ophtha.2009.09.003. Epub 2010 Jan 4.
To evaluate the distribution of central corneal thickness (CCT) and its associations in an adult Indian population.
Population-based study.
The Central India Eye and Medical Study is a population-based study performed in a rural region close to Nagpur in Central India; it included 4711 subjects (ages 30+ years) of 5885 eligible subjects (response rate, 80.1%).
The participants underwent a detailed ophthalmic and medical examination, including 200 standardized questions on socioeconomic background, lifestyle, social relations, and psychiatric depression. This study was focused on CCT as measured by sonography and its associations. Intraocular pressure was measured by applanation tonometry.
Central corneal thickness and intraocular pressure.
Central corneal thickness measurement data were available on 9370 (99.4%) eyes. Mean CCT was 514+/-33 microm (median, 517 microm; range, 290-696 microm). By multiple regression analysis, CCT was associated significantly with younger age (P<0.001), male gender (P<0.001), higher body mass index (P = 0.006), lower corneal refractive power (P<0.001), deeper anterior chamber (P = 0.02), thicker lens (P = 0.02), and shorter axial length (P = 0.006). Central corneal thickness was not associated significantly with refractive error (P = 0.54) or cylindrical refractive error (P = 0.20). If eyes with a corneal refractive power of 45 or more diopters were excluded, the relationship between CCT and axial length was no longer statistically significant (P>0.05), whereas all other relationships remained significant. Intraocular pressure readings increased significantly (P<0.001) with both higher CCT and higher corneal refractive power.
Indians from rural Central India have markedly thinner corneas than do Caucasians or Chinese, and, as in other populations, CCT is greater in men. CCT was associated with younger age, higher body mass index, lower corneal refractive power, deeper anterior chamber, thicker lens, and shorter axial length. Intraocular pressure readings were associated with CCT, with high readings in those eyes that had thick corneas or steep corneas. Central corneal thickness and steepness of the anterior corneal surface may thus both have to be taken into account when applanation tonometry is performed.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
评估印度成年人中央角膜厚度（CCT）的分布及其相关性。
基于人群的研究。
印度中部眼与医学研究是一项基于人群的研究，在印度中部那格浦尔附近的一个农村地区进行；共纳入 4711 名（年龄≥30 岁）符合条件的 5885 名受试者中的 4711 名（应答率为 80.1%）。
参与者接受了详细的眼科和医学检查，包括 200 个关于社会经济背景、生活方式、社会关系和精神抑郁的标准化问题。本研究主要关注超声测量的 CCT 及其相关性。眼压通过压平眼压计测量。
中央角膜厚度和眼压。
9370 只（99.4%）眼可获得中央角膜厚度测量数据。平均 CCT 为 514±33µm（中位数，517µm；范围，290-696µm）。通过多元回归分析，CCT 与年龄较小（P<0.001）、男性（P<0.001）、较高的体重指数（P=0.006）、较低的角膜屈光力（P<0.001）、较深的前房（P=0.02）、较厚的晶状体（P=0.02）和较短的眼轴（P=0.006）显著相关。CCT 与屈光不正（P=0.54）或圆柱状屈光不正（P=0.20）无显著相关性。如果排除角膜屈光力为 45 度或以上的眼睛，CCT 与眼轴的关系不再具有统计学意义（P>0.05），而其他所有关系仍然显著。眼压读数随 CCT 和角膜屈光力的增加而显著升高（P<0.001）。
来自印度中部农村地区的印度人比白种人和中国人的角膜薄得多，而且与其他人群一样，男性的 CCT 更大。CCT 与年龄较小、体重指数较高、角膜屈光力较低、前房较深、晶状体较厚和眼轴较短有关。眼压读数与 CCT 相关，角膜较厚或角膜陡峭的眼睛读数较高。因此，在进行压平眼压测量时，不仅要考虑 CCT，还要考虑前角膜表面的陡峭程度。
作者在本文讨论的任何材料中均无专有或商业利益。
