Błaszczyk B, Giełdanowski J, Karakoz I
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):743-6.
Experimental allergic encephalomyelitis (EAE) in chickens of the inbred lines IC, CB, WB and (CBxIC)F1 hybrids was investigated. The IC line and (CBxIC)F1 hybrids gave the best reactions. In bursectomized chickens only slight changes in brain were observed. The intensity of EAE in thymectomized chickens was highly suppressed. Using the anti-T and anti-B sera it was shown that, the percentage of EAE of B lymphocytes was increased. Among the used several immunosuppressive drugs which generally decreased inflammatory reactions in brain the best results were observed with azathioprine and actinomycin D. Moreover, cyclophosphamide gave the worse results which was shown in the same experiments. The aim of our experiments was to define the role of thymus and bursa of Fabricius and peripheral B and T lymphocytes in the course of EAE. Moreover, the effect of immunosuppressive drugs on EAE was studied.
对近交系IC、CB、WB和（CBxIC）F1杂交鸡的实验性变应性脑脊髓炎（EAE）进行了研究。IC系和（CBxIC）F1杂交鸡的反应最佳。在法氏囊切除的鸡中，仅观察到大脑有轻微变化。胸腺切除的鸡中EAE的强度受到高度抑制。使用抗T和抗B血清表明，B淋巴细胞的EAE百分比增加。在所使用的几种通常会降低脑部炎症反应的免疫抑制药物中，硫唑嘌呤和放线菌素D的效果最佳。此外，在相同实验中显示，环磷酰胺的效果最差。我们实验的目的是确定胸腺、法氏囊以及外周B和T淋巴细胞在EAE病程中的作用。此外，还研究了免疫抑制药物对EAE的影响。
