Departamento de Investigacion y Posgrado en Alimentos, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Col. Centro, 83000 Hermosillo, Sonora, Mexico.
Departamento de Ingenieria Quimica y Metalurgia, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Col. Centro, 83000 Hermosillo, Sonora, Mexico.
Curr Protein Pept Sci. 2019;20(12):1204-1217. doi: 10.2174/1389203720666190430110647.
Legume proteins are precursors of bioactive components, such as peptides. In the present paper, different types of legume as sources of bioactive peptides and hydrolysates are considered and discussed based on their anti-inflammatory effect. Peptides with anti-inflammatory activity were included from in vitro and in vivo studies. Current strategies for obtaining bioactive peptides, as well as their structure and impact on health, were also reviewed. It was discovered that peptides derived from legume protein, mainly soybean and bean, can regulate several inflammatory markers, which include prostaglandin E2 (PGE2), nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX- 2), cytokines, and chemokines. So far, lunasin, VPY and γ-glutamyl peptides have been identified with anti-inflammatory activity but their mechanisms have not been fully elucidated. Furthermore, it is necessary to gather more information about hydrolysates containing peptides and single peptides with antiinflammatory activity. Considering the wide diversity, legume may be promising components to produce peptides efficient to ameliorate inflammatory disorders.
豆类蛋白质是生物活性成分（如肽）的前体。本文主要考虑不同类型的豆类作为生物活性肽和水解产物的来源，并基于其抗炎作用进行了讨论。所包含的抗炎活性肽来自体外和体内研究。本文还综述了获得生物活性肽的当前策略及其结构和对健康的影响。研究发现，来源于豆类蛋白质（主要是大豆和豆类）的肽可以调节几种炎症标志物，包括前列腺素 E2（PGE2）、一氧化氮（NO）、诱导型一氧化氮合酶（iNOS）、环氧化酶 2（COX-2）、细胞因子和趋化因子。到目前为止，已经确定具有抗炎活性的 lunasin、VPY 和 γ-谷氨酰肽，但它们的机制尚未完全阐明。此外，有必要收集更多关于含有肽的水解产物和具有抗炎活性的单一肽的信息。考虑到广泛的多样性，豆类可能是生产有效改善炎症性疾病的肽的有前途的成分。
