Gliński W, Haftek M, Obałek S, Jabłońska S
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):755-60.
Patients with psoriasis were found to have less intensive experimental DNCB sensitization and decreased lymphocyte response to nonspecific mitogens, PHA, Con A, and PWM. E rosette formation was defective only in active psoriasis, in contrast to normal T and B cell counts. A reduction in DNCB hypersensitivity development and the percentage of E rosette forming lymphocytes were related to disease activity, but not to extention of skin lesions. The defect of E rosette function appeared to be transitional and completely disappeared in the remission. Abnormalities in CMI in psoriasis were found to be related at least partially to the existence in patients sera of a factor inhibiting normal T lymphocyte function. The study provides no evidence for the presence of primary CMI defect in psoriasis.
研究发现，银屑病患者的二硝基氯苯（DNCB）实验性致敏强度较低，对非特异性有丝分裂原、植物血凝素（PHA）、刀豆蛋白A（Con A）和美洲商陆有丝分裂原（PWM）的淋巴细胞反应降低。与正常的T细胞和B细胞计数相比，E花环形成仅在活动性银屑病中存在缺陷。DNCB超敏反应的发展以及E花环形成淋巴细胞的百分比降低与疾病活动相关，但与皮肤病变的范围无关。E花环功能缺陷似乎是暂时的，在缓解期完全消失。银屑病中细胞介导免疫（CMI）异常至少部分与患者血清中存在抑制正常T淋巴细胞功能的因子有关。该研究没有提供证据表明银屑病存在原发性CMI缺陷。
