Blackmur James P, Melquiot Nadja, Robertson Katherine E, Teahan Seamus
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Urology Department, NHS Forth Valley, Larbert, UK.
BMJ Case Rep. 2019 Jun 16;12(6):e228904. doi: 10.1136/bcr-2018-228904.
A 43-year-old woman and a 73-year-old man were referred separately from primary care to the urology service with short histories of frank haematuria. In both cases, histology from transurethral resection of their bladder tumours demonstrated the rare clear cell variant of urothelial/transitional cell carcinoma. Staging scans found the former patient had low-volume local disease, and the latter had locally advanced disease. The former patient went on to have partial cystectomy and pelvic lymph node dissection (with the endoscopic portion of the partial cystectomy undertaken by holmium:YAG laser), while the latter was found to have inoperable disease, and proceeded to chemotherapy. The former patient was alive with no evidence of disease recurrence at 45 months, while the latter was alive but with extensive lymph nodal recurrence at 45 months.
一名43岁女性和一名73岁男性因出现肉眼血尿病史较短，分别从基层医疗转诊至泌尿外科。在这两例病例中，经尿道膀胱肿瘤切除术的组织学检查均显示为罕见的尿路上皮/移行细胞癌透明细胞变体。分期扫描发现，前一名患者为低容量局部疾病，后一名患者为局部晚期疾病。前一名患者接受了部分膀胱切除术和盆腔淋巴结清扫术（部分膀胱切除术的内镜部分由钬:钇铝石榴石激光完成），而后一名患者被发现患有无法手术的疾病，因此接受了化疗。前一名患者在45个月时存活，无疾病复发迹象，而后一名患者在45个月时存活，但出现广泛的淋巴结复发。
