Rotellini Matteo, Fondi Cristina, Paglierani Milena, Stomaci Niceta, Raspollini Maria Rosaria
Department of Human Pathology and Oncology, University of Florence, Italy.
Appl Immunohistochem Mol Morphol. 2010 Jul;18(4):396-9. doi: 10.1097/PAI.0b013e3181d57dce.
Clear cell transitional carcinoma of the bladder is a subtype of transitional carcinoma that morphologically resembles a clear cell renal cell carcinoma. Although kidney tumors do not frequently metastasize to the bladder, the recurrence after a clear cell renal cell carcinoma has been reported even several years after nephrectomy. We report the case of a male patient to whom radical nephrectomy for a clear cell renal cell carcinoma has been done, with a bladder tumor featuring polygonal cells with abundant clear cytoplasm deeply infiltrating the vesical wall. We discuss the morphologic features, the immunohistochemical staining with a new marker and the UroVysion FISH analysis to achieve a definitive diagnosis.
膀胱透明细胞移行癌是移行癌的一种亚型，其形态学上类似于透明细胞肾细胞癌。虽然肾肿瘤很少转移至膀胱，但有报道称透明细胞肾细胞癌患者在肾切除术后数年仍会复发。我们报告一例男性患者，该患者因透明细胞肾细胞癌接受了根治性肾切除术，其膀胱肿瘤具有多边形细胞，胞质丰富且透明，肿瘤细胞深深浸润膀胱壁。我们讨论了其形态学特征、使用一种新标志物的免疫组化染色以及UroVysion荧光原位杂交分析，以做出明确诊断。
