Kramer Mario W, Abbas Mahmoud, Pertschy Stefanie, Becker Jan Ulrich, Kreipe Hans-Heinrich, Kuczyk Markus A, Merseburger Axel S, Tezval Hossein
Department of Urology and Urologic Oncology.
Rare Tumors. 2012 Oct 10;4(4):e48. doi: 10.4081/rt.2012.e48.
Clear cell variants of transitional cell carcinomas (TCC) of the bladder are extremely rare tumors. Only 6 cases have been reported until now. We report of a 67 year old man who presented with fast growing tumor disease. While initial diagnosis showed localized bladder tumor, final histopathology revealed pT4, G3, L1 urothelial carcinoma with clear cell differentiation. No more than 14 weeks after initial diagnosis the patient died from multi-organ failure after unsuccessful salvage laparotomy which showed massive tumor burden within the pelvis and peritoneal carcinosis. This case demonstrated an extremely fast tumor growth. Therefore, patients with clear cell urothelial carcinoma should be treated vigorously and without time delay. We present a case of clear cell variant of TCC which exhibited an extremely aggressive behavior. To our knowledge this is the fifth report of this rare disease.
膀胱移行细胞癌（TCC）的透明细胞变体是极其罕见的肿瘤。迄今为止，仅报告过6例。我们报告了一名67岁男性，他患有快速生长的肿瘤疾病。最初诊断显示为局限性膀胱肿瘤，但最终组织病理学显示为pT4、G3、L1伴透明细胞分化的尿路上皮癌。在最初诊断后不到14周，患者在挽救性剖腹手术失败后死于多器官功能衰竭，该手术显示盆腔内有大量肿瘤负荷和腹膜癌转移。该病例显示肿瘤生长极其迅速。因此，透明细胞尿路上皮癌患者应积极且不延迟地进行治疗。我们报告了一例表现出极具侵袭性的TCC透明细胞变体病例。据我们所知，这是该罕见疾病的第五例报告。
