Gastroenterology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia.
Gastroenterology Unit, Faculty of Medicine, Universiti Teknologi MARA, 47000, Sungai Buloh, Selangor, Malaysia.
Dig Dis Sci. 2020 Feb;65(2):541-549. doi: 10.1007/s10620-019-05695-3. Epub 2019 Jun 17.
This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients.
A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified Garrigues questionnaires for pre- and post-consumption were assessed.
Median intestinal transit time was significantly reduced from 58 (IQR 43-72) to 45 (IQR 24-59) hours and 48 (IQR 31-72) to 30 (IQR 24-49) hours for Groups A and B, respectively (p < 0.01). Fecal pH for Groups A and B was significantly reduced from 6.57 ± 0.96 to 6.13 ± 0.95 (p = 0.003) and 6.58 ± 1.0 to 5.87 ± 0.83 (p < 0.001), respectively. Fecal weight for Group A was significantly increased from 8 g ± 6.4 g to 9.8 g ± 7.6 g (p = 0.003), but it was reduced for Group B from 13.3 g ± 19.4 g to 11.2 g ± 6.6 g (p = 0.308). Constipation-related symptoms were significantly improved for both groups.
The addition of polydextrose to sterilized probiotic containing L. helveticus did not show significant benefits to constipation-predominant irritable bowel syndrome patients. However, daily consumption of sterilized probiotic containing L. helveticus with or without polydextrose for a week alleviated constipation-related symptoms and objectively reduced both fecal pH and intestinal transit time.
本研究旨在客观地探讨在含有瑞士乳杆菌的灭菌益生菌中添加聚葡萄糖是否会给以便秘为主的肠易激综合征患者带来益处。
共有 163 名患者被随机分为两组：A 组每天摄入 350 毫升含 5.85 克聚葡萄糖的灭菌益生菌，共 1 周；B 组不添加聚葡萄糖。评估肠道转运时间、粪便 pH 值、粪便重量和使用改良 Garrigues 问卷进行治疗前后评估。
A 组和 B 组的中位肠道转运时间分别从 58（IQR 43-72）小时降至 45（IQR 24-59）小时和 48（IQR 31-72）小时降至 30（IQR 24-49）小时（p<0.01）。A 组和 B 组的粪便 pH 值分别从 6.57±0.96 降至 6.13±0.95（p=0.003）和 6.58±1.0 降至 5.87±0.83（p<0.001）。A 组粪便重量从 8 g±6.4 g 显著增加至 9.8 g±7.6 g（p=0.003），但 B 组从 13.3 g±19.4 g 减少至 11.2 g±6.6 g（p=0.308）。两组便秘相关症状均显著改善。
在含有瑞士乳杆菌的灭菌益生菌中添加聚葡萄糖对以便秘为主的肠易激综合征患者没有显著益处。然而，每周摄入含瑞士乳杆菌的灭菌益生菌或含或不含聚葡萄糖均可缓解便秘相关症状，并客观地降低粪便 pH 值和肠道转运时间。
