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Autophagy-induced degradation of Notch1, achieved through intermittent fasting, may promote beta cell neogenesis: implications for reversal of type 2 diabetes.

作者信息

DiNicolantonio James J, McCarty Mark

机构信息

Mid America Heart Insitute, Kansas, Kansas, USA.

Catalytic Longevity, Encinitas, California, USA.

出版信息

Open Heart. 2019 May 22;6(1):e001028. doi: 10.1136/openhrt-2019-001028. eCollection 2019.

DOI:10.1136/openhrt-2019-001028
PMID:31218007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6546199/
Abstract
摘要

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本文引用的文献

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Pharmacological levels of hydrogen sulfide inhibit oxidative cell injury through regulating the redox state of thioredoxin.药理水平的硫化氢通过调节硫氧还蛋白的氧化还原状态来抑制氧化细胞损伤。
Free Radic Biol Med. 2019 Apr;134:190-199. doi: 10.1016/j.freeradbiomed.2019.01.009. Epub 2019 Jan 11.
2
Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure.量化补充螺旋藻对血浆脂质和葡萄糖浓度、体重及血压的影响。
Diabetes Metab Syndr Obes. 2018 Nov 14;11:729-742. doi: 10.2147/DMSO.S185672. eCollection 2018.
3
Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic β-cell autophagy.油酸盐破坏 cAMP 信号转导，导致胰腺β细胞自噬的强烈刺激。
J Biol Chem. 2019 Jan 25;294(4):1218-1229. doi: 10.1074/jbc.RA118.004833. Epub 2018 Dec 5.
4
Effectiveness of plant-based diets in promoting well-being in the management of type 2 diabetes: a systematic review.植物性饮食在2型糖尿病管理中促进健康的有效性：一项系统综述。
BMJ Open Diabetes Res Care. 2018 Oct 30;6(1):e000534. doi: 10.1136/bmjdrc-2018-000534. eCollection 2018.
5
Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice.间歇性给予模拟禁食饮食可干预小鼠糖尿病进展、恢复β细胞并重建肠道微生物群。
Nutr Metab (Lond). 2018 Nov 20;15:80. doi: 10.1186/s12986-018-0318-3. eCollection 2018.
6
A plant-based diet in overweight individuals in a 16-week randomized clinical trial: metabolic benefits of plant protein.在一项为期 16 周的随机临床试验中，超重个体的植物性饮食：植物蛋白的代谢益处。
Nutr Diabetes. 2018 Nov 2;8(1):58. doi: 10.1038/s41387-018-0067-4.
7
Notch signaling dynamically regulates adult β cell proliferation and maturity.Notch 信号动态调节成年 β 细胞增殖和成熟。
J Clin Invest. 2019 Jan 2;129(1):268-280. doi: 10.1172/JCI98098. Epub 2018 Dec 3.
8
Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complications.抗氧化剂胆红素通过多种方式发挥作用，以降低肥胖及其健康并发症的风险。
Open Heart. 2018 Oct 16;5(2):e000914. doi: 10.1136/openhrt-2018-000914. eCollection 2018.
9
Intermittent administration of a leucine-deprived diet is able to intervene in type 2 diabetes in mice.间歇性给予亮氨酸缺乏饮食能够干预小鼠的2型糖尿病。
Heliyon. 2018 Sep 27;4(9):e00830. doi: 10.1016/j.heliyon.2018.e00830. eCollection 2018 Sep.
10
Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.精氨酸的变化与 2 型糖尿病呈负相关：PREDIMED 试验中的病例-队列研究。
Diabetes Obes Metab. 2019 Feb;21(2):397-401. doi: 10.1111/dom.13514. Epub 2018 Oct 2.