Thiele H G, Arndt R, Hamann A, Stark R
Eur J Immunol. 1979 Feb;9(2):130-5. doi: 10.1002/eji.1830090207.
A molecule with an apparent molecular weight of 21,000 daltons was found to be a predominating differentiation antigen of peripheral rat T lymphocytes. This antigen is also expressed on the cell surface of thymus lymphocytes though partially in masked form. The observation that these determinants could be unmasked by neuraminidase treatment in vitro suggests that enzymatic processes may play an important role in antigenic transformation along the differentiation pathway of T axis lymphocytes. Since this structure was found to be displayed also by peritoneal exudate macrophages, it is referred to as T lymphocyte-macrophage antigen. The finding that an identical antigen could be identified in the mouse suggests its more common biological significance.
一种表观分子量为21,000道尔顿的分子被发现是外周大鼠T淋巴细胞的主要分化抗原。这种抗原也表达于胸腺淋巴细胞的细胞表面，不过部分是以隐蔽形式存在。体外经神经氨酸酶处理后这些决定簇可被暴露这一观察结果表明，酶促过程可能在T轴淋巴细胞分化途径的抗原转化中起重要作用。由于发现这种结构也存在于腹腔渗出巨噬细胞中，故将其称为T淋巴细胞-巨噬细胞抗原。在小鼠中也能鉴定出相同抗原这一发现提示了其更普遍的生物学意义。
