Linde AG, Linde Healthcare, Pullach, Germany.
Present Address : Faculty of Medicine, University of Porto, Porto, Portugal.
BMC Pulm Med. 2019 Jun 20;19(1):109. doi: 10.1186/s12890-019-0870-2.
Evaluating severity of illness of patients with prolonged mechanical ventilation (PMV) is important to adopt the best appropriate care management for each individual. Yet, no severity-of-illness scoring system has been specifically designed for this type of patients. The aim of this study was to develop and validate a new instrument, the Multi-INdependence Dimensions (MIND) questionnaire designed to comprehensively measure the severity of illness of patients under PMV.
The validation of the MIND questionnaire was performed during a longitudinal observational study conducted with PMV subjects in weaning facilities in three countries (Argentina, Colombia and Germany). The questionnaire validity was tested in 3 stages: 1) Specification of components, with description of item responses, inter-item and Cronbach alpha correlations; 2) Creation of the composite scores; 3) Measurement properties determination including test-retest reliability after 30 days, clinical validity (Medical Research Council (MRC) muscle strength score, Sepsis-related Organ Failure Assessment (SOFA), Glasgow Coma Scale (GCS), Dependence Nursing Scale and EuroQol-5 Dimension evaluated at inclusion), and ability to detect change.
A total of 128 subjects participated in the validation study. Eleven component scores and four composite scores were created. MIND scores significantly correlated with MRC muscle strength, SOFA, DNS, GCS and EQ-5D, supporting the validity of the new scores. Intraclass Correlation Coefficient greater than 0.82 were observed for all composite scores, indicating good test-retest reliability. MIND scores were able to detect improvement in subject severity of illness.
The MIND questionnaire is a valid and reliable instrument for measuring comprehensively the multiple dimensions characterizing the severity of illness of PMV patients.
NCT02255058 .
评估长时间机械通气（PMV）患者的疾病严重程度对于为每个个体提供最佳的适当护理管理非常重要。然而，目前还没有专门为这种类型的患者设计的疾病严重程度评分系统。本研究旨在开发和验证一种新的工具，即多依赖维度（MIND）问卷，用于全面衡量接受 PMV 的患者的疾病严重程度。
在阿根廷、哥伦比亚和德国的三个脱机设施中进行的一项纵向观察性研究中，对 MIND 问卷进行了验证。问卷的有效性在三个阶段进行了测试：1）组件的规范，描述项目反应、项目间和 Cronbach alpha 相关性；2）创建综合评分；3）确定测量特性，包括 30 天后的重测信度、临床有效性（肌肉力量评分、与脓毒症相关的器官衰竭评估、格拉斯哥昏迷量表、依赖护理量表和欧洲五维健康量表在纳入时进行评估）和检测变化的能力。
共有 128 名患者参与了验证研究。创建了 11 个分量表和 4 个综合评分。MIND 评分与 MRC 肌肉力量、SOFA、DNS、GCS 和 EQ-5D 显著相关，支持新评分的有效性。所有综合评分的组内相关系数均大于 0.82，表明重测信度良好。MIND 评分能够检测到患者疾病严重程度的改善。
MIND 问卷是一种有效且可靠的工具，可全面衡量 PMV 患者疾病严重程度的多个维度。
NCT02255058 。
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