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白细胞介素2(IL-2)在环形泰勒虫感染的牛淋巴细胞增殖中的作用。

The role of interleukin 2 (IL 2) in the proliferation of Theileria annulata-infected bovine lymphocytes.

作者信息

Ahmed J S, Hauschild S, Schein E

机构信息

Institut für Parasitologie und Tropenveterinärmedizin, Freien Universität Berlin.

出版信息

Parasitol Res. 1987;73(6):524-6. doi: 10.1007/BF00535327.

Abstract

The role of interleukin 2 (IL 2) in the proliferation of Theileria annulata-infected lymphoblastoid cells was studied. It was found that these cells neither require nor produce IL 2. This was based on the following findings: (a) The growth of T. annulata-infected cells was not enhanced by addition of IL 2 to the culture medium. (b) IL 2-dependent Con A-stimulated bovine peripheral blood lymphocytes (Con A-blasts) no longer required IL 2 after being infected with sporozoites of T. annulata. (c) The supernatants of T. annulata-infected cells did not support growth of IL 2-dependent Con A-blasts.

摘要

研究了白细胞介素2(IL-2)在环形泰勒虫感染的淋巴母细胞样细胞增殖中的作用。发现这些细胞既不需要也不产生IL-2。这是基于以下发现:(a)向培养基中添加IL-2并不能增强环形泰勒虫感染细胞的生长。(b)IL-2依赖的伴刀豆球蛋白A刺激的牛外周血淋巴细胞(伴刀豆球蛋白A母细胞)在感染环形泰勒虫子孢子后不再需要IL-2。(c)环形泰勒虫感染细胞的上清液不能支持IL-2依赖的伴刀豆球蛋白A母细胞的生长。

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