Hopsu-Havu V K, Joronen I, Rinne A, Järvinen M
Department of Dermatology, University of Turku, Finland.
Acta Histochem. 1987;82(1):19-24. doi: 10.1016/S0065-1281(87)80089-2.
We have used immunohistochemical and quantitative immunochemical techniques to study the tissue distribution of the 43 kDa papain inhibiting protein, originally isolated from psoriatic scale. High amounts of the inhibitor were found in the epidermis only in several skin diseases where the epidermal cell proliferation was increased (psoriasis, various eczemas). The inhibitor was also found in the basal cells of the bronchial epithelium and in the squamous epithelia of mouth and oesophagus, and the Hassal's corpuscles of the thymus. Sera of patients suffering from several skin diseases did not contain the inhibitor, but antibodies against it were found in the sera of two patients suffering from leg ulceration. The inhibitor was immunologically unrelated to filaggrin, involucrin, or keratins.
我们运用免疫组织化学和定量免疫化学技术，研究了最初从银屑病鳞屑中分离出的43 kDa木瓜蛋白酶抑制蛋白的组织分布情况。仅在几种表皮细胞增殖增加的皮肤病（银屑病、各种湿疹）的表皮中发现了大量该抑制剂。在支气管上皮的基底细胞、口腔和食管的鳞状上皮以及胸腺的哈氏小体中也发现了该抑制剂。患有几种皮肤病的患者血清中不含该抑制剂，但在两名患有腿部溃疡的患者血清中发现了针对它的抗体。该抑制剂在免疫上与丝聚蛋白、内披蛋白或角蛋白无关。
