Järvinen M, Rinne A, Hopsu-Havu V K
Department of Pathology, University of Oulu, Finland.
Acta Histochem. 1987;82(1):5-18. doi: 10.1016/S0065-1281(87)80043-0.
Immunohistochemica and quantitative immunochemical methods were used to demonstrate the presence of two cysteine proteinase inhibitors, cystatins A and B, in normal and diseased tissues. Cystatin A is expressed in squamous epithelia, neutrophil granulocytes, and dendritic reticulum cells of the lymphatic tissues. Its concentration is increased in inflammatory skin diseases and decreases after the malignization of squamous epithelia. Cystatin B is seen in wet squamous epithelia, and in the cells of monocyte-macrophage series, where its concentration varies depending on the activation state of the cells. In the malignant keratinocytes cystatin B follows the behaviour of cystatin A.
采用免疫组织化学和定量免疫化学方法，在正常组织和病变组织中证实两种半胱氨酸蛋白酶抑制剂——胱抑素A和胱抑素B的存在。胱抑素A在鳞状上皮、中性粒细胞和淋巴组织的树突状网状细胞中表达。其浓度在炎症性皮肤病中升高，在鳞状上皮恶变后降低。胱抑素B见于湿润的鳞状上皮以及单核细胞-巨噬细胞系列细胞中，其浓度随细胞的激活状态而变化。在恶性角质形成细胞中，胱抑素B的表现与胱抑素A一致。
