促甲状腺激素对促甲状腺激素释放激素的反应作为抑郁症患者自杀风险的生物学标志物。

The thyrotropin response to thyrotropin-releasing hormone as a biological marker of suicidal risk in depressive patients.

作者信息

Kørner A, Kirkegaard C, Larsen J K

机构信息

Department of Psychiatry, Frederiksberg Hospital, Copenhagen, Denmark.

出版信息

Acta Psychiatr Scand. 1987 Oct;76(4):355-8. doi: 10.1111/j.1600-0447.1987.tb05618.x.

DOI:10.1111/j.1600-0447.1987.tb05618.x

PMID:3122525

Abstract

In order to evaluate a possible predictive value for committing suicide of a reduced thyrotropin-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) stimulation we studied 306 depressed patients. The patients were followed for a mean of 5.8 (SD 2.9) years. During this period, 18 patients committed suicide. The TSH response to TRH stimulation in these 18 patients who committed suicide was lower than in the patients who did not commit suicide. The difference is not statistically significant. It is concluded that the TSH response to TRH cannot be said to identify the patients who later commit suicide.

摘要

为了评估促甲状腺激素释放激素（TRH）刺激后促甲状腺激素（TSH）反应降低对自杀的可能预测价值，我们研究了306例抑郁症患者。患者平均随访5.8（标准差2.9）年。在此期间，18例患者自杀。这18例自杀患者对TRH刺激的TSH反应低于未自杀患者。差异无统计学意义。结论是，不能说TRH刺激后的TSH反应能识别出后来自杀的患者。