Meng Xianyi, Bozec Aline
Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, 91054, Germany.
Cell Stress. 2018 Mar 22;2(4):94-95. doi: 10.15698/cst2018.04.133.
Hypoxia-inducible factors (HIFs) are essential transcription factors for the cellular response to hypoxia. Expression and stabilization of HIFs can be triggered by hypoxia or by other factors under pathological stress such as inflammation and infection. Indeed, regulatory function of HIFs has been implicated in a variety of different immune cells like macrophages and T cells. In our recent study, we delineated HIF-1α and HIF-2α roles in B cells (Nat Commun, 9:251). We demonstrated that lack of HIF-1α in B cells leads to impaired IL-10-producing CD1dCD5 B cells expansion by modulating their glycolytic metabolism. We identified HIF-1α as a critical transcriptional factor involved in IL-10 production by B cells, thereby influencing the course of autoimmune diseases.
缺氧诱导因子（HIFs）是细胞对缺氧反应所必需的转录因子。HIFs的表达和稳定性可由缺氧或病理应激（如炎症和感染）下的其他因素触发。事实上，HIFs的调节功能已涉及多种不同的免疫细胞，如巨噬细胞和T细胞。在我们最近的研究中，我们阐述了HIF-1α和HIF-2α在B细胞中的作用（《自然通讯》，9:251）。我们证明，B细胞中缺乏HIF-1α会通过调节其糖酵解代谢导致产生IL-10的CD1dCD5 B细胞扩增受损。我们确定HIF-1α是参与B细胞产生IL-10的关键转录因子，从而影响自身免疫性疾病的进程。
