免疫母细胞在包括乳腺、腹腔、肠道和皮肤在内的血管外组织中的积聚。
The accumulation of immunoblasts in extravascular tissues including mammary gland, peritoneal cavity, gut and skin.
作者信息
Rose M L, Parrott D M, Bruce R G
出版信息
Immunology. 1978 Aug;35(2):415-23.
The migration of [125I]UdR labelled mesenteric (MLN) and peripheral T immunoblasts (PLN) has been followed in mice with multiple sites attractive to immunoblasts. The sites studied were the inflamed gut (produced by Trichinella spiralis infection), inflamed skin, the peritoneal cavity and the mammary glands of lactating mice. PLN were capable of assembling in all of the four sites and in the presence of both inflamed gut and inflamed skin, PLN accumulated preferentially in the skin. MLN, in contrast migrated only to the gut and mammary glands and not to the skin or peritoneal cavity, and could not be diverted from one site to another. Time course experiments revealed that whereas PLN migrate rapidly through the inflamed gut, they are retained in the skin for at least 3 days.
已对[125I]尿苷标记的肠系膜（MLN）和外周T免疫母细胞（PLN）在具有多个吸引免疫母细胞位点的小鼠体内的迁移情况进行了跟踪研究。所研究的位点包括发炎的肠道（由旋毛虫感染引起）、发炎的皮肤、腹腔以及泌乳小鼠的乳腺。PLN能够在所有这四个位点聚集，并且在发炎的肠道和发炎的皮肤同时存在的情况下，PLN优先在皮肤中积累。相比之下，MLN仅迁移至肠道和乳腺，而不迁移至皮肤或腹腔，并且不能从一个位点转移至另一个位点。时间进程实验表明，PLN虽然能快速穿过发炎的肠道，但它们会在皮肤中滞留至少3天。
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