初次免疫反应期间的局部血流及其与淋巴细胞和淋巴母细胞运输的关系。
Regional blood flow and its relationship to lymphocyte and lymphoblast traffic during a primary immune reaction.
作者信息
Ottaway C A, Parrott D M
出版信息
J Exp Med. 1979 Aug 1;150(2):218-30. doi: 10.1084/jem.150.2.218.
The relationship of alterations in blood flow with changes in cell distribution has been studied in an inflammatory site and its draining lymph node during the induction of an immune reaction with oxazolone in mice. The cells which move to the site of inflammation are predominantly lymphoblasts and their increased localization in the inflamed ear is significantly correlated with increased regional blood flow to the inflamed tissue. The existence of this correlation is not antigen dependent although there is a relative increment of lymphoblasts which are specifically primed to the inflammatory agent. The localization of nonblastic (small) 51Cr-labeled lymphocytes on the other hand is substantial only in lymphoid tissue and during the induction of an immune reaction after oxazolone application, the increase in localization of these cells in the draining lymph node is positively correlated with increased blood flow to the node. Furthermore, the probability of finding 51Cr labeled lymphocytes in a particular lymph node is related to the regional blood flow which that node receives.
在小鼠用恶唑酮诱导免疫反应期间，研究了炎症部位及其引流淋巴结中血流变化与细胞分布改变之间的关系。迁移至炎症部位的细胞主要是淋巴母细胞，它们在发炎耳部的定位增加与流向发炎组织的局部血流增加显著相关。尽管存在对炎症因子特异性致敏的淋巴母细胞相对增加，但这种相关性的存在并不依赖于抗原。另一方面，非母细胞性（小）51Cr标记淋巴细胞仅在淋巴组织中大量存在，在应用恶唑酮后诱导免疫反应期间，这些细胞在引流淋巴结中的定位增加与流向该淋巴结的血流增加呈正相关。此外，在特定淋巴结中发现51Cr标记淋巴细胞的概率与该淋巴结接受的局部血流有关。
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