Lyscom N, Brueton M J
Clin Exp Immunol. 1983 Oct;54(1):158-62.
Small intestinal intraepithelial (IEL) and Peyer's patch (PPL) lymphocytes of newborn rats have been studied in histological sections and in isolated cell suspensions. Initially IEL numbers were low compared with older animals, and fewer cells were labelled by the monoclonal antibody markers used. At birth, 41% of IEL expressed receptors for MRC OX8 (T suppressor marker) yet lacked receptors for W3/13 (pan-T marker) which was present on only 1% of these cells. IEL with receptors for W3/25 (T helper marker) were not seen until 2 weeks of age. Granulated cells (GIEL) accounted for only 19% of IEL at birth. The numbers and relative proportions of these lymphocyte sub-types were still not mature at the time of weaning. In the first week of life there was a short lived upsurge in numbers of GIEL and MRC OX8+ IEL. The relative distribution of PPL sub-types was mature 4 weeks after birth, but the morphology of this tissue did not appear to be well differentiated until 1 week later.
对新生大鼠的小肠上皮内（IEL）淋巴细胞和派尔集合淋巴结（PPL）淋巴细胞进行了组织学切片和分离细胞悬液研究。最初，与成年动物相比，IEL数量较少，且使用的单克隆抗体标记物标记的细胞也较少。出生时，41%的IEL表达MRC OX8受体（T抑制标记），但缺乏W3/13受体（全T标记），这些细胞中只有1%存在W3/13受体。直到2周龄才见到具有W3/25受体（T辅助标记）的IEL。出生时颗粒细胞（GIEL）仅占IEL的19%。这些淋巴细胞亚群的数量和相对比例在断奶时仍未成熟。在出生后的第一周，GIEL和MRC OX8 + IEL的数量出现短暂激增。PPL亚群的相对分布在出生后4周成熟，但该组织的形态直到1周后才似乎得到充分分化。
