在人体中无法用抗B淋巴细胞血清（抗DRW）阻断淋巴细胞Fc受体。

Failure to block lymphocyte Fc receptor with anti-B lymphocyte sera (anti-DRW) in man.

作者信息

Soulillou J P, Peyrat M A

出版信息

Immunology. 1979 Mar;36(3):519-25.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457570/

Abstract

Sera harvested from multiparous women or from allograft recipients who had rejected their kidneys and containing various anti-DRW specificities, were studied on peripheral blood or lymph-node lymphocytes bearing or lacking the relevant B-cell alloantigen, for their EA or EAC-rosette-inhibition activity. Inhibition of C3 or Fc-receptor occurred independently of their anti-B lymphocyte cytotoxicity pattern. The same conclusion was reached when lymphocytes were either macrophage depleted or B-lymphocyte enriched. These results do not suggest a relationship in man between B-lymphocyte (DRW) alloantigen and Fc or C3 receptor structure.

摘要

从多产妇女或已发生肾排斥反应的同种异体移植受者身上采集的血清，含有各种抗DRW特异性抗体，研究其对带有或缺乏相关B细胞同种异体抗原的外周血或淋巴结淋巴细胞的EA或EAC玫瑰花结抑制活性。C3或Fc受体的抑制作用与其抗B淋巴细胞细胞毒性模式无关。当淋巴细胞巨噬细胞耗竭或B淋巴细胞富集时，也得出了相同的结论。这些结果并不表明在人类中B淋巴细胞（DRW）同种异体抗原与Fc或C3受体结构之间存在关联。

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本文引用的文献

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Supravital blood studies, using acridine orange fluorescence.采用吖啶橙荧光法进行的体外活体血液研究。

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Receptors for immune complexes on lymphocytes.淋巴细胞上免疫复合物的受体

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Inhibition of complement-dependent lymphocyte rosette formation: a possible test for activated complement products.补体依赖性淋巴细胞玫瑰花结形成的抑制：一种检测活化补体产物的可能方法。

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The possible biological significance of Fc receptors on mammalian lymphocytes and tumor cells.Fc受体在哺乳动物淋巴细胞和肿瘤细胞上的潜在生物学意义。

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5

Evidence for identity or close association of the Fc receptor of B lymphocytes and alloantigens determined by the Ir region of the H-2 complex.关于B淋巴细胞的Fc受体与由H-2复合体的Ir区域所决定的同种异体抗原的同一性或紧密关联的证据。

J Exp Med. 1974 Sep 1;140(3):779-96. doi: 10.1084/jem.140.3.779.

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4a(W4) and 4b(W6) human histocompatibility antigens are specifically associated with complement receptors.

Nature. 1975 Dec 25;258(5537):732-4. doi: 10.1038/258732a0.

7

Inhibition of lymphocyte mitogenesis by immobilized antigen-antibody complexes.固定化抗原-抗体复合物对淋巴细胞有丝分裂的抑制作用。

J Exp Med. 1975 Oct 1;142(4):814-26. doi: 10.1084/jem.142.4.814.

8

Interactions of Fc receptors with antibodies against Ia antigens and other cell surface components.Fc受体与抗Ia抗原及其他细胞表面成分抗体的相互作用。

J Exp Med. 1975 May 1;141(5):1201-9. doi: 10.1084/jem.141.5.1201.

9

Interaction of K lymphocytes with myeloma proteins of different IgG subclasses.K淋巴细胞与不同IgG亚类骨髓瘤蛋白的相互作用。

J Immunol. 1976 Nov;117(5 Pt 1):1464-71.

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Detection of anti-donor "Ia" antibodies: a strong correlate of rejection.

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