Wilson A B, Prichard-Thomas S, Coombs R R
Immunology. 1979 Jun;37(2):377-84.
In a survey of lymphocyte subpopulations in normal guinea-pig blood, lymph node, spleen, thymus and peritoneal cavity, a considerable overlap was observed between the percentages of C3-receptor bearing lymphocytes (CRL) and of thymus-dependent (T) cells in lymph nodes. Simultaneous rosette-formation reactions with sheep erythrocytes carrying rabbit complement (EAC) and papain-treated rabbit erythrocytes (a T-cell marker) revealed that 20--50% of the lymph node CRL were T lymphocytes. These experiments and others on cell suspensions depleted of Ig-bearing (B) lymphocytes showed that between 8 and 36% of lymph node T cells have complement receptors. The frequency of T-CRL in other lymphoid tissues was lower, representing between 0 and 8% of the T-cell population. The reaction of T-CRL and EAC was not inhibited by EDTA which is known to inhibit the C3 receptor activity on macrophages.
在一项对正常豚鼠血液、淋巴结、脾脏、胸腺和腹腔中淋巴细胞亚群的调查中，观察到淋巴结中携带C3受体的淋巴细胞（CRL）百分比与胸腺依赖性（T）细胞百分比之间存在相当大的重叠。用携带兔补体的绵羊红细胞（EAC）和木瓜蛋白酶处理的兔红细胞（一种T细胞标志物）同时进行玫瑰花结形成反应，结果显示20%至50%的淋巴结CRL是T淋巴细胞。这些实验以及其他针对去除了携带Ig的（B）淋巴细胞的细胞悬液所做的实验表明，8%至36%的淋巴结T细胞具有补体受体。其他淋巴组织中T-CRL的频率较低，占T细胞群体的0%至8%。已知EDTA可抑制巨噬细胞上的C3受体活性，但T-CRL与EAC的反应不受其抑制。
