Tucović Dina, Popov Aleksandrov Aleksandra, Popović Dušanka, Malešević Anastasija, Subota Vesna, Brdarić Emilija, Soković Bajić Svetlana, Živković Milica, Kataranovski Milena, Mirkov Ivana, Stanojević Stanislava, Kulaš Jelena
Immunotoxicology Group, Department of Ecology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Institute for Medical Biochemistry, Military Medical Academy, 11000 Belgrade, Serbia.
Biology (Basel). 2025 May 16;14(5):557. doi: 10.3390/biology14050557.
Although obesity and metabolic syndrome (comprising at least three of the following traits-abdominal obesity, elevated blood pressure, triglycerides and glucose/insulin resistance, and reduced high-density lipoprotein cholesterol in serum) are known to impact immune system activity, these conditions are often not considered when immune response characteristics are investigated in various rodent strains. In this work, metabolic syndrome indices are compared in 3 month-old (young) and 6 month-old (adult) rats of Dark Agouti (DA) and Albino Oxford (AO) strains, while parameters of coagulation, inflammation and oxidative stress were determined in young animals. Study reveals that both young and adult AO rats are obese, intolerant to glucose with higher levels of triglycerides and lower levels of high-density lipoprotein cholesterol when compared to age-matched DA rats. Parameters of coagulation, inflammation and oxidative stress that may contribute to the worsening of metabolic syndrome during aging are also higher in young AO rats. Metabolic syndrome observed in young and intensified in adult AO rats should be taken into consideration when analyzing alterations in immune reactivity during aging in this rat strain.
虽然肥胖和代谢综合征（包括以下至少三种特征——腹部肥胖、血压升高、甘油三酯和血糖/胰岛素抵抗以及血清中高密度脂蛋白胆固醇降低）已知会影响免疫系统活性，但在研究各种啮齿动物品系的免疫反应特征时，这些情况往往未被考虑。在这项工作中，比较了3月龄（幼年）和6月龄（成年）的暗褐鼠（DA）和牛津白化鼠（AO）品系大鼠的代谢综合征指标，同时测定了幼年动物的凝血、炎症和氧化应激参数。研究表明，与年龄匹配的DA大鼠相比，幼年和成年AO大鼠均肥胖，对葡萄糖不耐受，甘油三酯水平较高，高密度脂蛋白胆固醇水平较低。在幼年AO大鼠中，可能导致衰老过程中代谢综合征恶化的凝血、炎症和氧化应激参数也较高。在分析该大鼠品系衰老过程中免疫反应性的变化时，应考虑幼年时观察到并在成年AO大鼠中加剧的代谢综合征。
