Juguilon Cody, Khosravi Ramak, Radisic Milica, Wu Joseph C
Stanford Cardiovascular Institute (C.J., J.C.W.), Stanford University, Stanford, CA.
Division of Cardiovascular Medicine, Department of Medicine (C.J., J.C.W.), Stanford University, Stanford, CA.
Circ Res. 2025 May 23;136(11):1476-1493. doi: 10.1161/CIRCRESAHA.125.325497. Epub 2025 May 22.
Cardiovascular-kidney-metabolic syndrome is a progressive disorder driven by perturbed interorgan crosstalk among adipose, liver, kidney, and heart, leading to multiorgan dysfunction. Capturing the complexity of human cardiovascular-kidney-metabolic syndrome pathophysiology using conventional models has been challenging. Multi-organ-on-a-chip platforms offer a versatile means to study underlying interorgan signaling at different stages of cardiovascular-kidney-metabolic syndrome and bolster clinical translation.
心血管-肾脏-代谢综合征是一种由脂肪、肝脏、肾脏和心脏之间器官间串扰驱动的进行性疾病，会导致多器官功能障碍。使用传统模型来捕捉人类心血管-肾脏-代谢综合征病理生理学的复杂性一直具有挑战性。多器官芯片平台提供了一种多功能手段，用于研究心血管-肾脏-代谢综合征不同阶段潜在的器官间信号传导，并促进临床转化。
