López Bernal A, Hansell D J, Alexander S, Turnbull A C
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford.
Br J Obstet Gynaecol. 1987 Nov;94(11):1052-8. doi: 10.1111/j.1471-0528.1987.tb02289.x.
The production of progesterone from pregnenolone, of cortisol from cortisone and of prostaglandin E (PGE) under basal and arachidonic acid-stimulated conditions was measured in cells dispersed from chorion and decidua. The cells were obtained after delivery from four groups of women: following spontaneous labour at term (38-42 weeks gestation), at elective caesarean section at term before the onset of labour, after induced labour at term, and after uncomplicated preterm (27-36 weeks) labour. Chorionic cells had a high progesterone output with relatively low cortisol and PGE production, whereas decidual cells had a high cortisol and PGE production rate. Free arachidonic acid stimulated PGE production in both decidual and chorionic cells. There were no significant differences in either steroid or PGE production among the four groups studied. These data suggest that steroid dehydrogenase activity in choriodecidual cells is not related to the mode of onset of labour and that the increased prostaglandin production in intrauterine tissues associated with parturition is due to enhanced availability of arachidonic acid.
在从绒毛膜和蜕膜分离出的细胞中，测定了基础状态和花生四烯酸刺激条件下孕烯醇酮生成孕酮、可的松生成皮质醇以及前列腺素E（PGE）的情况。这些细胞取自四组产妇分娩后：足月自然分娩（妊娠38 - 42周）、足月择期剖宫产（临产前）、足月引产以及无并发症的早产（27 - 36周）后。绒毛膜细胞孕酮产量高，皮质醇和PGE产量相对较低，而蜕膜细胞皮质醇和PGE生成率高。游离花生四烯酸刺激蜕膜和绒毛膜细胞中的PGE生成。在所研究的四组中，类固醇或PGE生成均无显著差异。这些数据表明，绒毛蜕膜细胞中的类固醇脱氢酶活性与分娩发动方式无关，且与分娩相关的子宫内组织中前列腺素生成增加是由于花生四烯酸可用性增强所致。
