儿童癌症幸存者化疗和放疗对牙齿结构的远期影响：系统评价和荟萃分析。
Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta-analysis.
机构信息
Department of Paediatric Dentistry, Athens School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Department of Orthodontics, 251 Greek Air Force Hospital, Athens, Greece.
出版信息
Head Neck. 2019 Sep;41(9):3422-3433. doi: 10.1002/hed.25840. Epub 2019 Jun 22.
BACKGROUND
This systematic review summarizes the prevalence of dental defects after chemo and radiation therapy and correlates the findings with specific characteristics of each treatment modality.
METHODS
Database search was performed for studies reporting dental late effects of chemo and radiation therapy. After data extraction and risk of bias assessment, prevalence of crown and root defects was assessed. Correlations between each defect and the characteristics of the antineoplastic treatment were performed.
RESULTS
Sixteen nonrandomized studies were included, yielding a total of 1300 patients with a mean age at diagnosis of 4.5 years. Results reported that root defects were more common than crown defects. The most common root defect was impaired root growth and microdontia the most common crown defect. Age, radiation dose and field were statistically associated with higher prevalence of dental defects.
CONCLUSION
Defects were associated with combination of chemotherapy and radiotherapy, as used in current therapeutic antineoplastic modalities.
背景
本系统综述总结了化疗和放疗后牙齿缺损的发生率，并将这些发现与每种治疗方式的具体特征相关联。
方法
对报道化疗和放疗后牙齿迟发性影响的研究进行数据库检索。在提取数据和评估偏倚风险后，评估了冠部和根部缺损的发生率。对每种缺陷与抗肿瘤治疗特征之间的相关性进行了分析。
结果
共纳入 16 项非随机研究，共计 1300 名患者，诊断时的平均年龄为 4.5 岁。结果表明，根部缺陷比冠部缺陷更为常见。最常见的根部缺陷是牙根生长受损和小牙畸形，最常见的冠部缺陷是釉质发育不全。年龄、辐射剂量和照射野与牙齿缺陷的高发生率呈统计学相关。
结论
缺陷与当前抗肿瘤治疗模式中使用的化疗和放疗联合治疗有关。
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