Aitbaev K A, Murkamilov I T, Fomin V V
Scientific and research Institute of molecular biology and medicine, 3 T.Moldo str., Bishkek 720040, Kyrgyzstan.
I.K.Akhunbaev Kyrgyz State Medical Academy, 92 Akhunbaev str., Bishkek 720020, Kyrgyzstan, e-mail:
Adv Gerontol. 2019;32(1-2):20-28.
Aging is a multifactorial process characterized by the gradual loss of physiological functions, which leads to increased vulnerability of the organism to age-related diseases and, finally, to death. To explain the nature of aging, several theories have been proposed, one of which relates aging to damage to cell structures and DNA caused by free radicals. However, an increasing amount of evidence suggests that molecular mechanisms of aging are also associated with epigenetic modifications, such as DNA methylation, non-coding RNA and histone changes. In this review, we will analyze the significance of the results of these studies and show how the interrelated effects of oxidative stress and epigenetics can explain the cause of the extinction of physiological functions during aging.
衰老 是一个多因素过程，其特征是生理功能逐渐丧失，这导致生物体对与年龄相关疾病的易感性增加，最终导致死亡。为了解释衰老的本质，人们提出了几种理论，其中一种理论将衰老与自由基对细胞结构和DNA的损伤联系起来。然而，越来越多的证据表明，衰老的分子机制也与表观遗传修饰有关，如DNA甲基化、非编码RNA和组蛋白变化。在这篇综述中，我们将分析这些研究结果的意义，并展示氧化应激和表观遗传学的相互关联效应如何解释衰老过程中生理功能丧失的原因。
