Department of Physiology, International University of Health and Welfare School of Medicine, Kozunomori 4-3, Narita, Chiba 286-8686, Japan; Division of Biology, Center for Molecular Medicine, Jichi Medical University, Yakushiji 3311-1, Shimotsuke, Tochigi 329-0498, Japan.
Department of Physiology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan.
Brain Res. 2019 Oct 1;1720:146289. doi: 10.1016/j.brainres.2019.06.008. Epub 2019 Jun 19.
The prevalence of delivery through cesarean-section (C-section) has been increasing worldwide. Although different modes of delivery, such as vaginal birth and C-section, are associated with incidence of some diseases in humans, little is known about how delivery stimuli affect short- and long-term brain function. Phenotypic analyses of Atp1a2 homozygous knockout (Atp1a2) neonates showed that the mode of delivery affected neural phenotypes; Atp1a2 mice born by vaginal delivery started spontaneous breathing, while Atp1a2 mice born by C-section showed a complete absence of breathing followed by their death. This life or death phenotype prompted us to examine several aspects of the neonatal brain following C-section or vaginal delivery. We found significantly different levels of several monoamines and transporters/channel proteins and a different c-Fos expression pattern. Furthermore, these mice showed different behaviors in adulthood. Our results suggest that birth mode impacts neurotransmission and functional network formation in the neonatal brain.
剖宫产（C -section）的流行率在全球范围内不断增加。虽然不同的分娩方式，如阴道分娩和剖宫产，与人类某些疾病的发生率有关，但对于分娩刺激如何影响短期和长期大脑功能知之甚少。Atp1a2 纯合敲除（Atp1a2）新生儿的表型分析表明，分娩方式会影响神经表型；通过阴道分娩出生的 Atp1a2 小鼠开始自主呼吸，而通过剖宫产出生的 Atp1a2 小鼠则完全没有呼吸，随后死亡。这种生死表型促使我们检查剖宫产或阴道分娩后新生儿大脑的几个方面。我们发现，几种单胺类物质和转运体/通道蛋白的水平以及 c-Fos 表达模式存在显著差异。此外，这些小鼠在成年期表现出不同的行为。我们的研究结果表明，分娩方式会影响新生儿大脑的神经传递和功能网络形成。
