Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, F-35000, Rennes, France.
Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, F-35000, Rennes, France.
Biochimie. 2019 Aug;163:171-183. doi: 10.1016/j.biochi.2019.06.013. Epub 2019 Jun 20.
Despite the improvement of diagnostic methods and anticancer therapeutics, the human population is still facing an increasing incidence of several types of cancers. According to the World Health Organization, this growing trend would be partly linked to our environment, with around 20% of cancers stemming from exposure to environmental contaminants, notably chemicals like polycyclic aromatic hydrocarbons (PAHs). PAHs are widespread pollutants in our environment resulting from incomplete combustion or pyrolysis of organic material, and thus produced by both natural and anthropic sources; notably benzo[a]pyrene (B[a]P), i.e. the prototypical molecule of this family, that can be detected in cigarette smoke, diesel exhaust particles, occupational-related fumes, and grilled food. This molecule is a well-recognized carcinogen belonging to group 1 carcinogens. Indeed, it can target the different steps of the carcinogenic process and all cancer hallmarks. Interestingly, H dynamics have been described as key parameters for the occurrence of several, if not all, of these hallmarks. However, information regarding the role of such parameters during environmental carcinogenesis is still very scarce. The present review will thus mainly give an overview of the impact of B[a]P on H dynamics in liver cells, and will show how such alterations might impact different aspects related to the finely-tuned balance between cell death and survival processes, thereby likely favoring environmental carcinogenesis. In total, the main objective of this review is to encourage further research in this poorly explored field of environmental molecular toxicology.
尽管诊断方法和抗癌疗法有所改善，但人类仍面临着几种癌症发病率不断上升的问题。根据世界卫生组织的数据，这种增长趋势部分与我们的环境有关，约 20%的癌症是由于暴露于环境污染物，特别是多环芳烃 (PAHs) 等化学物质引起的。PAHs 是我们环境中广泛存在的污染物，它们是有机物质不完全燃烧或热解产生的，因此来源于自然和人为来源；其中苯并[a]芘 (B[a]P) 是该家族的典型分子，可在香烟烟雾、柴油尾气颗粒、职业相关烟雾和烧烤食物中检测到。这种分子是一种公认的致癌物，属于 1 类致癌物。事实上，它可以针对致癌过程的不同步骤和所有癌症特征。有趣的是，H 动力学已被描述为发生这些特征的关键参数之一。然而，关于这些参数在环境致癌过程中的作用的信息仍然非常稀缺。因此，本综述将主要概述 B[a]P 对肝细胞中 H 动力学的影响，并展示这些改变如何影响与细胞死亡和存活过程之间的精细平衡相关的不同方面，从而可能有利于环境致癌。总的来说，本综述的主要目的是鼓励在这个环境分子毒理学领域进行进一步研究。
